How to Treat Upper Gastrointestinal Cancers in 2025 - Treatment Algorithm

Welcome to another episode of the Oncology Brothers! In this episode, Drs. Rahul and Rohit Gosain are joined by their brother, Dr. Timothy Brown from UT Southwestern, to discuss the latest treatment paradigms for upper gastrointestinal (GI) malignancies, specifically focusing on esophageal and gastroesophageal junction adenocarcinoma, as well as gastric cancer.

Episode Highlights:
•⁠  ⁠Early Disease Management: perioperative FLOT versus concurrent chemoradiation.
•⁠  ⁠Adjuvant Nivolumab: Insights from the Checkmate 577 trial and its implications for patients with residual disease post-chemoradiation.
•⁠  ⁠Biomarker Testing: The importance of testing for MSI, HER2, Claudin 18.2, and PD-L1 to guide treatment decisions in metastatic settings.
•⁠  ⁠Patient-Centered Care: Emphasizing the significance of shared decision-making and multidisciplinary approaches in managing complex cases.

Join us as we unpack the nuances of upper GI malignancies and share key takeaways from recent studies and clinical practices. 

YouTube: https://youtu.be/UNyi71u2wIw

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