In this episode of Daily Value, we look at the neurometabolic potential of methylene blue, a synthetic dye first synthesized in the 19th century, for supporting brain energy metabolism during aging. Originally developed for textile use, methylene blue has since demonstrated potential use as a redox-active agent in neuroprotection and memory enhancement (and how exactly it performs these actions).

We look at it’s unique biochemical mechanism as an alternative electron carrier within the mitochondrial electron transport chain, showing how it may bypass dysfunctional complexes to enhance ATP production and reduce oxidative stress.

The episode also discusses findings from animal models and human trials, including the challenges and inconsistencies observed in clinical studies - along with potential risks, contraindications, and the implications for aging-related cognitive decline.

00:00 Introduction to Methylene Blue

00:57 Historical Background and Early Uses

02:31 Methylene Blue in Modern Medicine

04:03 Mechanisms of Action in the Brain

05:59 Dosage and Effects

12:23 Human Studies and Clinical Trials

15:35 Safety Concerns and Contraindications

18:16 Conclusion and Future Directions

PMID: 22067440

PMID: 34943887

PMID: 38022191

PMID: 36803299

Methylene Blue and the Bioenergetics of Memory