Modern Thyroid and Wellness

44: The #1 Hormone Women Aren’t Testing – The Best Way to Protect Fertility & Pregnancy with McCall McPherson

Aug 7, 2025
Explore the surprising impact of thyroid health on fertility and pregnancy outcomes. Discover how even mild thyroid dysfunction can disrupt conception and increase miscarriage risks. Learn why relying solely on TSH tests is outdated, especially during pregnancy, and the critical role of hormones like free T3 and progesterone. McCall McPherson emphasizes the importance of comprehensive testing and personalized hormone management for optimal reproductive health and postpartum recovery.
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INSIGHT

Mild Thyroid Dysfunction Lowers Fertility

  • Mild or subclinical thyroid dysfunction meaningfully reduces fertility and pregnancy success rates.
  • Small TSH shifts within the 'normal' range correlate with lower live birth and embryo quality rates.
ADVICE

Target Lower TSH Before Conception

  • Aim for a TSH under about 1.8 and ideally close to 1 before conception.
  • Do not accept ‘high-normal’ TSH (2.5–4.5) as optimal when pursuing fertility or IVF.
INSIGHT

T3 Matters For Egg Quality And Implantation

  • T3 strongly influences egg quality, ovulation, luteal function and implantation.
  • T3 and T4 needs can coexist and should be directly measured rather than inferred from TSH.
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