Heavy Lies the Helmet Episode 118 - Trigger Warning: Angioedema
Mar 25, 2024
A deep dive into the complexities of angioedema, covering diagnosis and treatment of IgE/Histamine-mediated and Bradykinin-mediated types. The discussion includes managing difficult airways, prompt epinephrine administration in anaphylaxis, and strategic medication use in emergencies. Emphasizing the importance of recognizing triggers and implementing life-saving measures in high-stress scenarios.
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Two Distinct Types Of Angioedema
- Angioedema splits into two main types: IgE (allergic) and bradykinin (non-IgE).
- Onset speed, itching, and skin redness help differentiate them quickly at bedside.
'Kitchen Sink' Treatment Obscures Effectiveness
- Clinicians often throw every anti-inflammatory and respiratory drug at angioedema without knowing the trigger.
- That 'kitchen sink' approach makes it hard to know which therapies actually helped.
Bradykinin Reactions Look Different
- Bradykinin-mediated angioedema rarely causes itching or redness and has a slower, more insidious onset.
- ACE inhibitors are a common culprit and can present even after weeks or months on therapy.