NEJM Interviews

NEJM Interview: Patricia Zettler on a proposed FDA rule on nicotine yields and potential challenges moving forward.

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Apr 16, 2025
In this engaging discussion, Patricia Zettler, a law professor at The Ohio State University, delves into the proposed FDA rule aiming to lower nicotine levels in tobacco products. She highlights the rule's potential to transform public health by combating nicotine addiction. Zettler also tackles the likely legal challenges from tobacco companies, emphasizing the tension between regulation and industry pushback. She encourages advocacy for the rule, urging researchers to support this pivotal shift in tobacco regulation.
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INSIGHT

FDA's Nicotine Limit Goal

  • The FDA rule aims to cap nicotine in cigarettes to reduce addiction and make quitting easier.
  • Lower nicotine levels can prevent youth addiction and reduce smoking-related diseases.
INSIGHT

Rule's Massive Health Impact

  • The nicotine rule could save millions of lives and generate trillions in benefits this century.
  • Its impact on public health would be one of the most significant regulations ever implemented.
INSIGHT

Anticipated Legal Challenges Explained

  • Tobacco companies will likely challenge the rule citing statutory limits against reducing nicotine to zero.
  • The FDA's proposed 0.7 mg/g nicotine cap is clearly not zero and is supported by research.
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