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Discovery Story of Cisplatin
- Barnet Rosenberg discovered cisplatin by observing E. coli cells exposed to platinum electrodes stop dividing.
- This unexpected result led to finding that cisplatin inhibits DNA replication, sparking cancer research.
Cisplatin Indicates Curative Therapy
- Cisplatin is mostly used for curative intent due to its high toxicity profile.
- Seeing a cisplatin order usually indicates the doctor aims to cure the cancer.
Hydration to Reduce Kidney Toxicity
- Prevent cisplatin nephrotoxicity by hydrating patients with normal saline to saturate chloride ions in kidneys.
- Use mannitol cautiously for forced diuresis; recent shortages made its role controversial but beneficial in high doses.