The Stem Cell Podcast

Ep. 50: Global Perspective Featuring George Daley of the Harvard Stem Cell Institute

Aug 4, 2015
In this insightful discussion, Dr. George Daley, a renowned stem cell biologist from Harvard, shares his journey from leukemia research to leading advancements in hematopoietic stem cell transplantation. He dives into the future of generating patient-specific blood stem cells and the challenges of directed differentiation. Daley emphasizes the continued importance of embryonic research alongside iPS technology. With light-hearted lab stories, he also touches on the ethical landscape and the exciting potential of CRISPR and organoids in transforming medicine.
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ANECDOTE

Career Origin In Blood Stem Cells

  • George Daley described his path from clinical leukemia research to stem cell science over three decades.
  • He framed blood stem cells as his entry point into a career bridging clinic and basic biology.
INSIGHT

Bone Marrow Transplant Is Proven But Imperfect

  • Hematopoietic stem cell transplant is a longstanding, curative stem cell therapy with real-world clinical successes.
  • George Daley highlighted persistent limitations: donor mismatch, complications, and significant patient mortality remain.
INSIGHT

Human Blood Stem Cell Generation Remains Slippery

  • Generating engraftable human hematopoietic stem cells from pluripotent cells remains elusive despite mouse success.
  • Daley's lab uses transcription-factor reprogramming of progenitors to create many blood lineages and aims for full engraftable HSCs.
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