
The Stem Cell Podcast Ep. 50: Global Perspective Featuring George Daley of the Harvard Stem Cell Institute
Aug 4, 2015
In this insightful discussion, Dr. George Daley, a renowned stem cell biologist from Harvard, shares his journey from leukemia research to leading advancements in hematopoietic stem cell transplantation. He dives into the future of generating patient-specific blood stem cells and the challenges of directed differentiation. Daley emphasizes the continued importance of embryonic research alongside iPS technology. With light-hearted lab stories, he also touches on the ethical landscape and the exciting potential of CRISPR and organoids in transforming medicine.
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Career Origin In Blood Stem Cells
- George Daley described his path from clinical leukemia research to stem cell science over three decades.
- He framed blood stem cells as his entry point into a career bridging clinic and basic biology.
Bone Marrow Transplant Is Proven But Imperfect
- Hematopoietic stem cell transplant is a longstanding, curative stem cell therapy with real-world clinical successes.
- George Daley highlighted persistent limitations: donor mismatch, complications, and significant patient mortality remain.
Human Blood Stem Cell Generation Remains Slippery
- Generating engraftable human hematopoietic stem cells from pluripotent cells remains elusive despite mouse success.
- Daley's lab uses transcription-factor reprogramming of progenitors to create many blood lineages and aims for full engraftable HSCs.
