Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: The Market Failure that Will Force Doctors to Keep Writing Opioid Prescriptions, published by mincho on June 8, 2024 on The Effective Altruism Forum.
This is an article of mine from Recursive Adaptation. We are always looking for new collaborators as we expand our research and policy development!
Excerpts
The Problem
Suzetrigine is a novel non-opioid, sodium channel painkiller with no addictive potential, from mid-size pharma company Vertex. It has shown
positive results in Phase 3 and is being submitted to the FDA for approval by the end of 2024 or early 2025. Suzetrigine is roughly equivalent in pain reduction efficacy to Vicodin (hydrocodone / APAP), which is one of the most commonly prescribed opioids.
We recently reviewed the efficacy and promise of suzetrigine in this article. There are other broad non-opioid painkillers in the pipelines of other companies that may arrive over the next few years.
This is great news - can we start removing opioids from medical treatment to prevent patients from developing addictions? Unfortunately, there's a huge obstacle: like other new medications, insurance providers will not pay for suzetrigine unless a doctor can show that a patient has tried a cheaper generic drug first and it was ineffective. And the cheaper generics for pain are opioids.
Next year, as tens of millions of Americans are getting teeth pulled, having surgeries, and suffering from chronic nerve pain, they will needlessly receive opioid prescriptions while a much safer alternative sits on the shelf waiting for its patent to expire a decade from now. About 3-6% of those patients who are prescribed opioids will become dependent, generating millions of completely avoidable new opioid addictions every year (
1,
2,
3). Non-patients will become addicted too, as many opioid addictions begin with prescriptions that were diverted from the original patient to someone else- leftover pills given to friends or discovered in a medicine cabinet.
Proposed Solution
Let's make a wild guess and say that Vertex expects to earn $100 million from suzetrigine in the US next year as a second-line treatment. That $100 million cost is already being borne by the public - through insurance premiums, taxes for Medicare and Medicaid, etc.
Instead, if the federal government can step in and offer Vertex $120 million in exchange for making suzetrigine available at generic prices, that would be a win for everyone - Vertex would make more money and remain incentivized to develop safer pain treatments and the public would pay only an extra 20% to get the drug to 5X or 10X or 20X as many people. The result is that those patients are safer, addictions are avoided, and huge downstream costs from addiction are saved.
Meanwhile, over the next few years, more non-opioid painkillers are expected to become available from other companies and once this arrangement is established, similar deals can be negotiated and renegotiated depending on market conditions.
This should be an obvious public health win. We should not be willing to accept a single day where suzetrigine is FDA approved but is being denied by insurance companies, forcing doctors to prescribe unnecessary opioids.
(More details of how this could be implemented are in the article)
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