GasGasGas - Anaesthetic Science for Anaesthesia! Stereoisomers & Chirality: Pharmacology Fundamentals for FRCA Primary
Sep 5, 2025
Dive into the fascinating world of molecular stereochemistry! Discover how the 3D arrangement of atoms in anaesthetic drugs can lead to beneficial or harmful effects. From exploring isomerism to understanding the crucial differences between types like positional and geometric isomers, the discussion highlights key examples such as isoflurane and mivacurium. Learn about enantiomers, their chiral centers, and notable drugs like warfarin that demonstrate the clinical importance of these concepts. It's a must-listen for future anaesthetists!
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Isomer Basics And Classification
- Isomers share the same molecular formula but differ in atomic arrangement, affecting properties.
- Classifications include structural isomers, stereoisomers, enantiomers and diastereoisomers.
Positional Isomers Change Drug Properties
- Positional isomers have identical atoms placed differently, changing physical properties.
- Example: n‑fluorane and isoflurane differ in boiling point and vapour pressure.
Tautomerism Alters Solubility
- Tautomers interconvert depending on environment such as pH, altering solubility.
- Thiopentone shifts from water‑soluble enol (alkaline) to lipid‑soluble keto (acidic plasma).