#199: The benefits, risks, and uses for GLP1s like Ozempic and Wegovy with McCall McPherson PA-C
Jan 2, 2025
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McCall McPherson, a Physician Assistant and founder of Modern Thyroid, shares her expertise on GLP-1 medications like Ozempic and Wegovy. She delves into their surprising benefits beyond weight loss, including their effects on brain chemistry, cravings, and metabolic health. McCall discusses the positive impacts on perimenopause and fertility, along with potential long-term risks. She emphasizes the need for personalized treatment and addresses public misconceptions, advocating for a more nuanced understanding of these medications in improving overall health.
GLP-1 medications like Ozempic and Wegovy can improve metabolic health by enhancing insulin sensitivity and regulating blood sugar levels.
While GLP-1s offer weight loss benefits, they may also reduce disease risks and support specific populations, including those in perimenopause.
Deep dives
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Mechanism and Effects of GLP-1 Medications
GLP-1 medications, like Ozempic and Wegovy, primarily work by enhancing insulin sensitivity and regulating blood sugar levels, making them effective for both diabetes management and weight loss. These medications interact with various GLP receptors throughout the body, influencing not only blood sugar metabolism but also neurochemistry and inflammation responses. Users often report reduced cravings and a diminished desire for unhealthy habits, including issues with alcohol and food addictions. This physiological effect can lead to significant behavioral changes, with some individuals experiencing increased comfort and a lower influx of harmful cravings.
Addressing Myths and Misconceptions
Many fears surrounding GLP-1 medications stem from misinformation and a focus on potential side effects rather than their numerous benefits. While some side effects like nausea and muscle loss can occur, these are often linked to incorrect dosages rather than the drugs themselves. Moreover, research indicates that these medications may actually reduce the risk of various cancers and cardiovascular diseases, challenging the narrative that they solely present risks. With a tailored approach to dosing, these medications have the potential to enhance metabolic health rather than detract from it.
Support for Diverse Populations
GLP-1 medications can provide significant benefits for specific populations, such as women in perimenopause and individuals struggling with autoimmune conditions. As metabolic health often declines during perimenopause, these medications may help mitigate weight gain and related health issues by targeting visceral fat. Additionally, evidence suggests these drugs can improve outcomes for individuals with autoimmune diseases, making them a valuable tool in the management of conditions like Hashimoto's and psoriatic arthritis. With ongoing research and a growing body of evidence, GLP-1s offer promising avenues for improving health across diverse demographics.
McCall McPherson, the founder of Modern Thyroid, is a Physician Assistant and Thyroid + Hormone expert. In today's episode, she explains why she often recommends GLP-1 drugs. She educates that while they can be used for weight loss, their uses extend far beyond weight loss.
0:00: Introduction 3:40: What are GLP-1s? 5:20: How do GLP-1s affect your brain chemistry? 8:45: Dosing GLP-1s, muscle loss, and exercise 13:08: Who can benefit from GLP-1s? 17:00: Side effects and risks of GLP-1s 23:20: Public perception of GLP-1s 25:57: GLP1s and perimenopause 28:38: Other benefits of GLP-1s 33:13: GLP1s and fertility 35:05: Are there long term risks of GLP-1s? 38:53: What to do if you're interested in starting GLP-1s 41:34: Symptoms of inflammation 42:27: McCall's final thoughts
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