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The Curious Clinicians
[Archive] - (Trans)locating the Bacteria
Feb 7, 2024
Debunking the belief of direct bacteria translocation in cirrhosis patients with SBP. Exploring the presence of intestinal bacterial overgrowth and its connection to various factors. Understanding the intricate bacterial pathway in SBP and the role of altered immunity. Emphasizing the relationship between SBP, bacteremia, and gram-negative bacteria in ascitic fluid.
21:25
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Quick takeaways
- Cirrhosis predisposes to SBP through mechanisms like altered immunity and bacterial overgrowth.
- Despite traditional beliefs, bacteria in SBP first translocate to mesenteric lymph nodes before reaching ascites.
Deep dives
Understanding Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is not caused by factors like bowel perforation but involves bacterial translocation from the gut into ascites. While the traditional belief was that bacteria cross directly into ascites, recent insights suggest a more intricate process. Cirrhosis leads to SBP through mechanisms such as intestinal bacterial overgrowth, increased permeability, and altered immunity, contributing to the risk of bacterial translocation.
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Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode