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VJHemOnc Podcast
iwAL 2022 Session IV: the evolving treatment landscape in ALL and the growing role of immunotherapies
Nov 22, 2022
Experts discuss the evolving treatment landscape in ALL and the role of immunotherapies like ADCs and CAR-T cells. They highlight the potential of targeted therapy and stopping therapy in pH positive ALL. The efficacy of cartizo for CNS infiltration and combination therapy for non-CNS EMD is discussed. The use of immunotherapies in ALL treatment is explored, including the benefits of combining therapies and optimizing immunotherapy. The effects of treatments on the immune system and tumor microenvironment in ALL are examined, including Punatine's impact on T-cells and NK-cells and the potential of LCK inhibition.
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Quick takeaways
- Targeted therapy using tyrosine kinase inhibitors and monoclonal antibodies has significantly improved outcomes for Philadelphia positive acute lymphoblastic leukemia.
- Cartisole therapy has shown effectiveness in crossing the blood-brain barrier and controlling CNS disease in Philadelphia positive ALL.
Deep dives
The Evolution of Therapy in Philadelphia Positive ALL
The podcast episode discusses the significant changes in therapy for Philadelphia positive acute lymphoblastic leukemia (ALL). Previously, prognosis for this subtype was poor, but now targeted therapy using tyrosine kinase inhibitors (TKIs) and monoclonal antibodies has improved outcomes. Studies have shown impressive results with overall survival and disease-free survival rates around 80%. This shift towards targeted therapies has reduced the need for transplants and opened doors for further advancements, such as the possibility of stopping therapy after several years.
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Discover
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Listen to the best highlights from the podcasts you love and dive into the full episode