Nutrition Diva Does Ozempic slow aging? Separating facts from hype
Sep 17, 2025
Is Ozempic the key to slowing down aging? This discussion dives into a study suggesting semaglutide might actually reverse biological aging by around 9%, especially in those living with HIV. It emphasizes the importance of scrutinizing sensational headlines while also highlighting the role of lifestyle choices in healthy aging. With insights on the use of epigenetic clocks and the need for more research, it urges listeners to question media hype and focus on evidence-backed approaches to longevity.
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Study Context Matters
- The semaglutide trial that sparked headlines was a 32-week randomized, double-blind, placebo-controlled study in people with HIV and lipohypertrophy.
- The anti-aging claim comes from a post-hoc analysis of samples collected during that specific trial.
Post-Hoc Preprint Requires Caution
- The epigenetic-aging analysis was post-hoc using stored blood samples and the study is currently a preprint.
- Post-hoc results and lack of peer review mean findings need confirmation before firm conclusions.
Epigenetic Clocks Show Youthful Shifts
- Researchers reported semaglutide slowed the pace of aging ~9% and participants measured about three years younger by epigenetic clocks.
- Specific systems like brain and cardiovascular markers showed larger apparent reductions in biological age.