TWiV 1260: Clinical update with Dr. Daniel Griffin

Oct 11, 2025

Dr. Daniel Griffin, an infectious diseases clinician and regular contributor, dives into pressing health topics. He discusses Jane Goodall’s legacy, the Nobel Prize discoveries on immune regulation, and the current measles epidemic affecting pregnant women. Griffin also highlights recent findings on COVID-19's impact on pregnancies and vascular dementia risk. In addition, he delves into the effectiveness of a two-dose influenza vaccine for young children and addresses long COVID in pediatrics, calling for urgent support for medical research.

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INSIGHT

Jane Goodall's Lasting Scientific Legacy

Jane Goodall's legacy reshaped how scientists treat and communicate about animals and conservation.
Griffin notes her influence on treating primates with dignity and inspiring women in science.

INSIGHT

Nobel Prize For T Regulatory Cells Explained

The 2025 Nobel honored discoveries about T regulatory cells and FOXP3's role in immune tolerance.
Griffin emphasizes this work reversed skepticism and enabled major advances in autoimmunity and cancer therapy.

ADVICE

Protect Advisory Committees From Political Vetting

Maintain independent scientific advisory bodies to evaluate vaccine policy rather than letting biased firms select members.
Griffin warns that allowing anti-science law firms to vet ACIP members risks harmful public-health decisions.

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In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about Jane Goodall’s death and the Nobel prize in Physiology/Medicine for understanding immune system control before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, if 2 doses of the influenza vaccine are better for protection of first season children, if COVID-19 negatively impacts pregnancy and the unborn child, efficacy of long-acting monoclonal antibody against symptomatic COVID-19, where to find PEMGARDA, how to access and pay for Paxlovid, can you be retreated with Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, long COVID in pediatrics, association of COVID-19 with new-onset vascular dementia and contacting your federal government representative to stop the assault on science and biomedical research.

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Links for this episode

Jane Goodall’s legacy: three ways she changed science (Nature)
They understood how the immune system is kept in check (The Nobel Prize)
Daniel Griffin: The Nobel Prize for Understanding Autoimmune Disease (WNYC: New York Public Radio)
Kennedy’s Ties to Ally Leading Vaccine Lawsuits Raise Ethical Concerns (NY Times)
Ebola outbreak in southern Congo shows signs of containment with no new cases, WHO reports (AP News)
Ebola Disease (WHO: African Region)
Premature baby dies from measles in Alberta as cases throughout province near 2,000(Global News)
DOH Issues Advisory After Measles Detection in City of Oswego Wastewater (Finger lakes dailynew.com)
Wastewater for measles (WasterWater Scan)
Measles cases and outbreaks (CDC Rubeola)
Tracking Measles Cases in the U.S. (Johns Hopkins)
Measles vaccine recommendations from NYP (jpg)
Weekly measles and rubella monitoring (Government of Canada)
Measles (WHO)
Get the FACTS about measles (NY State Department of Health)
Measles (CDC Measles (Rubeola))
Measles vaccine (CDC Measles (Rubeola))
Presumptive evidence of measles immunity (CDC)
Contraindications and precautions to measles vaccination (CDC)
Measles (CDC Measles (Rubeola))
Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America)
Deaths following vaccination: what does the evidence show (Vaccine)
Influenza: Waste water scan for 11 pathogens (WastewaterSCan)
US respiratory virus activity (CDC Respiratory Illnesses)
Respiratory virus activity levels (CDC Respiratory Illnesses)
Weekly surveillance report: clift notes (CDC FluView)
Influenza-Associated Pediatric Deaths — United States, 2024–25 Influenza Season (CDC: MMWR)
ACIP Recommendations Summary (CDC: Influenza)
American Academy of Pediatrics
Flu and Children (CDC: Influenza (flu))
Comparison of 2 Doses vs 1 Dose in the First Season Children Are Vaccinated Against Influenza (JAMA: Open Network)
Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA)
RSV: Waste water scan for 11 pathogens (WastewaterSCan)
US respiratory virus activity (CDC Respiratory Illnesses)
RSV-Network (CDC Respiratory Syncytial virus Infection)
Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV))
Economic Analysis of Protein Subunit and mRNA RSV vaccination in Adults aged 50-59 Years (CDC: ACIP)
Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases)
Efficacy and safety of respiratory syncytial virus vaccines(Cochrane Library)
Waste water scan for 11 pathogens (WastewaterSCan)
COVID-19 deaths (CDC)
Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)
COVID-19 national and regional trends (CDC)
COVID-19 variant tracker (CDC)
SARS-CoV-2 genomes galore (Nextstrain)
Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV)
Neonatal outcomes among pregnant women with COVID-19 (BMC Pregnancy and Childbirth)
Safety and Efficacy of Pemivibart, a Long-Acting Monoclonal Antibody, for Prevention of Symptomatic COVID-19 (CID)
Where to get pemgarda (Pemgarda)
EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
Infusion center (Prime Fusions)
CDC Quarantine guidelines (CDC)
NIH COVID-19 treatment guidelines (NIH)
Drug interaction checker (University of Liverpool)
Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro)
Understanding Coverage Options (PAXCESS)
Retreatment With Nirmatrelvir/Ritonavir Following Return of COVID-19 Symptoms and SARS-CoV-2 Positivity (CID)
Infectious Disease Society guidelines for treatment and management (ID Society)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What to do when sick with a respiratory virus (CDC)
Managing healthcare staffing shortages (CDC)
Anticoagulation guidelines (hematology.org)
Daniel Griffin’s evidence based medical practices for long COVID (OFID)
Long COVID hotline (Columbia : Columbia University Irving Medical Center)
The answers: Long COVID
Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR) (LANCET: Infectious Diseases)
Prevalence and duration of clinical symptoms of pediatric long COVID (Frontiers in Pediatrics)
COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years(NPJ| dementia) Reaching out to US house representative
Letters read on TWiV 1260
Dr. Griffin’s COVID treatment summary (pdf)
Timestamps by Jolene Ramsey. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Content in this podcast should not be construed as medical advice.