Teens who identify as transgender have high rates of depression, anxiety, eating disorders, substance abuse, self-harm and suicide. Primary care providers are in a unique position to inquire about gender development as part of routine well-child care and be a trusted source of support and information for patients and families. Sarah Hart-Unger, MD, endocrinologist at Joe DiMaggio Children’s dives into the endocrine issues and how pediatricians can provide gender-affirmative medical care for transgender and gender-diverse youth. Published June 2019. This podcast is for general informational and educational purposes only and is not to be considered as medical advice for any particular patient. Clinicians must rely on their own informed clinical judgment in making recommendations to their patients. ©2019 by Children's Hospital of Philadelphia, all rights reserved.