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Epinephrine's Importance
- Administer epinephrine immediately if you suspect anaphylaxis, regardless of blood pressure.
- It's better to manage slightly elevated blood pressure than to have none at all.
IV Epinephrine Advantages
- While intramuscular epinephrine is appropriate, intravenous epinephrine offers advantages in the ICU.
- IV epinephrine allows for faster onset, easier titration, and quicker reversal if needed.
Dirty Epi Drip
- Create a "dirty epi drip" by adding 1mg of epinephrine (from a cardiac or IM dose) to 1L of saline.
- This creates a 1 mcg/mL solution, minimizing overdose risk and simplifying titration.


