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VJHemOnc Podcast

Improving the efficiency of drug approvals in MDS

Sep 14, 2022
Experts Hetty Carraway and Justin Taylor discuss improving drug approvals in MDS. They cover challenges of treating high-risk disease, novel targets of interest, and more. Collaboration between NCI and cooperative groups in clinical trials, biomarker significance, accelerating drug approvals, and individualizing treatment strategies are also explored.
16:02

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Quick takeaways

  • Collaborative efforts between the National Cancer Institute and cooperative groups are crucial in developing clinical trials and finding therapies for Myelodysplastic Syndromes (MDS) patients.
  • Precision medicine approaches such as the Milo Match program, which screens patients for specific mutations and matches them to suitable clinical trials, hold promise for finding effective therapies for individual MDS patients.

Deep dives

Improving Efficacy of Drug Approvals in MDS

The podcast episode features discussions on improving the efficacy of drug approvals in Myelodysplastic Syndromes (MDS), featuring insights from experts in the field. The speakers address the heterogeneity of MDS and the need for precision medicine approaches to better match patients with appropriate clinical trials. They highlight the importance of collaborative efforts between the National Cancer Institute and cooperative groups to develop clinical trials and find therapies for MDS patients. The session also focuses on challenging patient populations, such as those with TP53 mutations, and explores potential treatments like APR246 and its impact on higher-risk MDS. The overall emphasis is on learning from these trials to refine future treatment approaches in MDS.

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