Turning the global frown upside down with America's top-ranking doctor

We begin this hour with the very latest on the Moscow terror attack, and the Princess of Wales’ cancer diagnosis, from CNN's Fredrika Whitfield. Then, the pursuit of health and happiness, in an emotional conversation with America's highest-ranking doctor, Vivek Murthy. The US Surgeon General, who wears his heart on his sleeve talking about his own struggles with loneliness, was in London for the World Happiness Summit this week. He says unchecked social media is like driving without speed limits - and he’s worried young people are losing the muscle memory to make meaningful human connections in the real world. Meantime, Israeli Prime Minister Benjamin Netanyahu says he’s pressing ahead with plans to evacuate more than a million civilians from Gaza's southern city of Rafah, before ramping up his offensive on Hamas. Critics say it will only make the humanitarian catastrophe worse. This week the International Rescue Committee (IRC) called the imminent famine in Gaza "a profound failure of humanity," and "entirely preventable." IRC chief and former UK foreign secretary, David Miliband, joins the show. From the Amanpour Archive this week, the last Soviet leader’s lost legacy, and Russia’s path to dictatorship. We revisit Christiane’s 2012 conversation with Mikhail Gorbachev, and the legacy Putin has spent decades dismantling. And finally, the poison pen letter scandal that rocked Britain. Oscar-winning actress Olivia Colman and director Thea Sharrock discuss their new movie Wicked Little Letters, and the satisfaction that get from swearing.

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