The Stem Cell Podcast

Ep. 293: “Cell Atlases” Featuring Dr. Sarah Teichmann

Apr 29, 2025
Guest
Sarah Teichmann
Join Dr. Sarah Teichmann, a leading stem cell researcher at the Cambridge Stem Cell Institute, as she dives into the fascinating world of cell plasticity and the Human Cell Atlas project. Discover how she merges computational techniques with traditional biology and the importance of interdisciplinary teams in advancing research. She also highlights breakthroughs in stem cell therapy for diseases like Parkinson's and innovative organoid technologies. Her insights promise to illuminate the future of personalized medicine!
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INSIGHT

Virtual Whole-Organ Cell Atlases

  • The Human Cell Atlas uses multimodal single-cell spatial genomics and computational approaches for comprehensive organ mapping.
  • This integration allows creation of virtual whole-organ cell atlases overcoming practical limitations of direct measurement.
ANECDOTE

Starting Single-Cell Genomics Journey

  • Early single-cell genomics work involved profiling handfuls of cells, which inspired imagining entire organisms mapped at single-cell level.
  • Sarah Teichmann's interdisciplinary position at Cambridge fostered collaboration, instrumental in founding the Single Cell Genomics Center with key scientists.
INSIGHT

Modeling Whole Organ Atlases

  • Future cell atlases will rely more on modeling and deep learning to generate 3D whole organ reconstructions.
  • Integrating molecular data with cellular morphology will deepen understanding of cells in tissue context.
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