492: Leaky Gut, Histamine Nightmare, and Your Nervous System: The Hidden Connection Making You Sick with The Gut Genie Laura Frontiero

Nov 11, 2025

Laura Frontiero, a functional gut-health practitioner, dives into the intricate connection between gut health, histamine, and the nervous system. She reveals how leaky gut goes beyond digestive issues, often leading to mysterious symptoms. Laura explains why popular diets like fermented foods may be counterproductive and emphasizes the dangers of perfectionism in healing. The conversation uncovers surprising links between gut health and Alzheimer's, while offering practical tools for managing histamine and nurturing your nervous system.

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INSIGHT

Gut As A Second Brain

The gut has its own enteric nervous system with over 100 million neurons that communicates instantly with the brain.
Dysregulation of this 'second brain' drives mood, digestion, and systemic inflammation.

ADVICE

Choose Doable Steps Over Perfection

Avoid perfectionism; doing 60–70% of healing steps consistently is enough to improve health.
Choose the one doable change that doesn't provoke stress because stress blocks healing.

INSIGHT

Leaky Gut Beyond Belly Pain

Leaky gut is intestinal permeability where tight junctions widen, allowing toxins and food particles into the bloodstream.
It often causes non-digestive symptoms like fatigue, brain fog, joint pain, and autoimmunity.

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Is your gut secretly controlling your brain, sabotaging your weight loss, and destroying your health – all while conventional medicine tells you it's "just stress"?

After diving deep into the research on histamine, mast cells, and the gut-brain connection (and texting Laura Frontiero approximately a million questions), I discovered why so many midlife women are struggling with mysterious symptoms that doctors can't explain. Laura reveals the shocking truth about leaky gut that has nothing to do with digestive symptoms, why fermented foods and bone broth might be making you worse, not better, and the dangerous mistake people make when trying to heal their gut. We uncover the instant connection between your brain and gut (proven by stroke research), why perfectionism is sabotaging your healing, and the surprising over-the-counter remedies that actually work for histamine issues. Plus, Laura shares why meditation might be stressing you out more, the unexpected link between gut health and Alzheimer's, and how estrogen dominance persists even after menopause. This conversation completely changed how I think about the stress-gut-brain connection and reveals why doing just 60% of things right is enough to heal.

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Learn More About Laura Frontiero

Instagram ➜ https://www.instagram.com/laura.frontiero

Website ➜ https://midlifeconversations.com/gut

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