Lyme disease can be challenging to distinguish from many common pediatric infections. Michael Russo, MD, attending physician in the Division of Infectious Diseases at Children’s Hospital of Philadelphia, reviews: disease history and incidence; disease stages, including early localized, early disseminated, and late; tips for distinguishing the Lyme-related symptoms bull’s-eye rash, facial palsy and arthritis from other ailments; indications for testing (and why tick-testing isn’t advised); amoxicillin, doxycycline, and ceftriaxone for different manifestations; duration of treatment; indications for post-exposure prophylaxis; and more. This podcast is for general informational and educational purposes only and is not to be considered as medical advice for any particular patient. Clinicians must rely on their own informed clinical judgment in making recommendations to their patients. ©2022 by Children's Hospital of Philadelphia, all rights reserved.