How I Invest with David Weisburd

E264: The Asymmetric Edge: Generating Alpha in Venture

11 snips
Dec 17, 2025
Jamie Lee, Co-founder and Managing Partner of Tamarack Global, dives into the secrets of spotting unicorn founders. He reveals how founder referrals are the most reliable indicators of success. Jamie discusses the importance of hedge-fund-level research and the role of intuition in investment decisions. He highlights the booming humanoid robotics market and how preempting rounds can lead to bigger wins. With insights from his experience at Coatue, he emphasizes that taking risks and trusting your gut are crucial for aspiring investors.
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INSIGHT

Founder Referrals Outperform Other Channels

  • Founder referrals are the single strongest sourcing signal for breakout startups.
  • Jamie Lee prioritizes calls from top founders and meets referred founders within 24 hours.
INSIGHT

Asymmetric Information Creates True Alpha

  • Tamarack seeks asymmetric information to outperform venture beta.
  • Jamie compares venture edge to public markets where unique kernels of information create alpha.
ADVICE

Bring Deep Diligence To Seed Rounds

  • Do apply hedge-fund-level diligence at the seed stage to win competitive rounds.
  • Jamie authors deep memos and shares research to help underwrite founders' next rounds.
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