TLC Sessions - Living with Long Covid Episode 20: Dr Betty Raman and Bill Hinshaw - Fatigue and the mitochondria
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Nov 23, 2021 In this insightful discussion, Dr. Betty Raman, an Oxford researcher studying the effects of Long Covid on the body, joins Bill Hinshaw, CEO of Axcella Therapeutics, who is developing innovative mitochondrial therapies. They dive into how mitochondrial dysfunction might drive the debilitating fatigue associated with Long Covid. The conversation highlights groundbreaking MRI findings revealing organ abnormalities and explores a promising treatment trial, AXA1125, aimed at restoring mitochondrial health and potentially alleviating fatigue for countless sufferers.
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Hosts' Recent Health Experiences
- Emily-Kate Stevens experienced a severe migraine, dizziness, and tinnitus flare-up after a viral infection.
- Noreen Jamil's heart issues worsened after a virus and booster shot, but later improved, while dizziness and eyesight deteriorated.
Organ Abnormalities in Long COVID
- Dr. Betty Raman's study revealed abnormalities in multiple organs of long COVID patients, including kidneys, heart, brain, and liver.
- These abnormalities manifest as changes in tissue magnetic properties, possibly due to increased water content, inflammation, or blood flow problems.
Multiple Phenotypes of Long COVID
- Long COVID presents with diverse symptoms, suggesting multiple phenotypes or clusters within the condition.
- Potential underlying mechanisms include ongoing inflammation, blood clots, mitochondrial dysfunction, and organ dysfunction.