This week to celebrate Thanksgiving, we are revisiting our episode with the one and only Matthew McConaughey (Dazed and Confused, Dallas Buyers Club)! Matthew helps us break down the science behind feeling and expressing gratitude, something especially important to focus on this time of year.

He also takes us on an electrifying journey through his intriguing life, from his intense childhood in which his parents divorced and remarried each other three times, to surviving off a head of lettuce with ketchup in Australia, to his current ambitions considering a run for political office. Matthew details his life-changing quests sparked by having the same wet dream twice and how he puts himself in positions to receive divine, prophetic messages from the universe. He explains why his dad was proud of him for getting into a bar fight, why he cries during births and not deaths, and why his son creates Powerpoint presentations to illustrate why Matthew is wrong. Mayim and Matthew discuss parenthood, and Matthew opens up about the sense of immortality he felt at the birth of his first child. Mayim also breaks down binding anxiety!

From the entire Mayim Bialik's Breakdown team, we want to wish all of you a very Happy Thanksgiving!

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StephCast F 12-19-25