The Orthobullets Podcast Pathology | Soft Tissue Sarcoma
Dec 4, 2025
Delve into the intriguing world of soft tissue sarcoma, where key epidemiological insights reveal patterns in incidence and demographics. Discover the genetic underpinnings including crucial translocations linked to syndromic conditions. The episode provides an engaging classification of various sarcoma subtypes along with essential staging principles. Learn about clinical signs, the role of imaging, and the importance of timely biopsy. Efficacious treatment strategies are discussed, spotlighting radiation's role and managing post-surgical complications.
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Sarcomas Are Diverse But Present Similarly
- Soft tissue sarcomas are a heterogeneous group of rare malignant soft tissue tumors with many subtypes distinguished by histology.
- They typically present as a slow-growing, painless soft tissue mass in patients older than 15 years.
Image Before You Biopsy
- Obtain plain radiographs first and then a contrast-enhanced MRI to evaluate any suspicious soft tissue mass prior to biopsy.
- If MRI is indeterminate or suggests sarcoma, perform a core needle or open biopsy before treatment.
Surgery Plus Radiation Is Standard
- Treat most soft tissue sarcomas with wide surgical resection plus radiation therapy to reduce local recurrence.
- Reserve chemotherapy mainly for rhabdomyosarcoma and Ewing sarcoma where it is standard of care.