Emergency Medical Minute
Episode 944: Colchicine Overdose
Feb 17, 2025
Dive into the fascinating world of colchicine, a drug used for treating gout and its surprising anti-inflammatory effects. Learn about the risks of colchicine overdose and how it can lead to multi-organ dysfunction. The episode highlights the critical phases of overdose, where patients may appear well while quietly suffering symptoms. Discover effective treatments, including gastrointestinal decontamination and advanced therapies like dialysis. This ancient drug reveals both its healing power and its potential dangers.
03:19
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Quick takeaways
- Colchicine, while effective in treating gout and reducing inflammation, has a narrow therapeutic index that increases overdose risks significantly.
- Prompt and aggressive treatment, including gastrointestinal decontamination and potential ECMO support, is essential for managing colchicine overdose effectively.
Deep dives
Colchicine Overview and Uses
Colchicine is primarily used in the treatment of gout, where it is typically prescribed in small doses. However, its application has expanded to include conditions like pericarditis and even long-term inflammation in patients with coronary artery disease. Recent studies suggest colchicine could help reduce the risk of heart attacks by managing inflammation associated with this disease. As medication use increases, it is crucial to be aware of its potential for overdose, given its narrow therapeutic window.
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