Emergency Medical Minute Episode 944: Colchicine Overdose
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Feb 17, 2025 Dive into the fascinating world of colchicine, a drug used for treating gout and its surprising anti-inflammatory effects. Learn about the risks of colchicine overdose and how it can lead to multi-organ dysfunction. The episode highlights the critical phases of overdose, where patients may appear well while quietly suffering symptoms. Discover effective treatments, including gastrointestinal decontamination and advanced therapies like dialysis. This ancient drug reveals both its healing power and its potential dangers.
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Expanding Uses of Colchicine
- Colchicine is mainly used for gout but also for pericarditis.
- New studies suggest benefits for long-term inflammation and coronary artery disease.
Colchicine Overdose Dangers
- Colchicine has a narrow therapeutic window.
- Overdosing can lead to multi-organ failure and cardiovascular collapse, requiring aggressive treatment.
Treat Colchicine Overdose Aggressively
- Treat colchicine overdose aggressively and early.
- This includes gastric lavage and cardiovascular support, potentially ECMO.