The 49ers' health woes continued after San Francisco lost superstar linebacker Fred Warner to a season-ending ankle injury in Sunday's loss to the Tampa Bay Buccaneers. San Francisco responded valiantly, managing to stay competitive throughout the matchup before fading late in the fourth quarter. Baker Mayfield and the Bucs' high-powered offense proved to be too much in the end as the 49ers suffered their second loss of the season. On this episode of '49ers Talk,' co-hosts Matt Maiocco and Jennifer Lee Chan discuss the potential ramifications of Warner's season-ending injury. They then detail Warner's impact on the 49ers organization from ownership to players and how San Francisco will feel his loss both on and off the field. Finally, they deliberate if Warner's injury signifies the beginning of the end in what started out as a promising 49ers' season?

(1:00) Fred Warner's season officially ends
(2:00) Warner's injury might be the most significant injury in Shanahan-Lynch era
(5:00) Warner might be the NFL's best player, the whole league loses when he's out
(8:00) Hard to ignore the similarities between HOF Patrick Willis and Fred Warner
(9:00) If Warner were to retire today, he might already be HOF-worthy
(11:00) Tatum Bethune steps into Warner’s roll - has strong relationship with Dee Winters already
(14:00) Now is the time for these young players to grow up in a hurry
(16:00) Without Warner the expectations of this team might need to be adjusted
(21:00) Mac Jones-Kendrick Bourne connection continues to produce
(22:00) Jennings-Shanahan altercation might be a storyline to continue to watch
(26:00) What is behind 49ers' run-game issues?

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Fred Warner's season-ending injury steals spotlight in 49ers' Week 6 loss to Buccaneers