emDOCs.net Emergency Medicine (EM) Podcast
Episode 94: GLP-1 Agonist Complications
Feb 7, 2024
Join Jess Pelletier and Brit Long on this episode as they delve into the world of GLP-1 agonists, discussing complications like pancreatitis and bowel obstruction, management strategies for gastrointestinal and dermatologic reactions, and debunking myths around premature aging and renal side effects.
10:24
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Quick takeaways
- GLP-1 agonists cause GI side effects like nausea, vomiting, diarrhea, pancreatitis, and bowel obstruction.
- GLP-1 agonists can lead to complications beyond GI issues, such as dermatologic reactions, acute kidney injury, and metabolic disturbances.
Deep dives
GLP-1 Agonists for Weight Loss
GLP-1 agonists like semiglutide and liraglutide have gained popularity for weight loss, particularly in patients with a BMI of 30 or over. These drugs stimulate insulin release from the pancreas, leading to reduced food intake, increased satiety, and ultimately weight loss. Common GI side effects, such as nausea, vomiting, and diarrhea, can be seen in 70% of patients, with rare but serious complications like pancreatitis or bowel obstruction. Patients presenting with these side effects may require a typical GI workup in the ED, including lipase and liver function tests, with management focused on IV fluid rehydration and symptom control.
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