In this episode, I spoke with Isabelle Kenyon, Founder & CEO at Calibrate, a metabolic health company on a mission to change the way the world treats weight. Since 2020, they have helped over 20,000 Americans improve metabolic health, showing results with members having averaged 15% sustained weight loss, surpassing the best outcomes from peer-reviewed clinical trials.

We cover:

How Isabelle started Calibrate by reading academic papers around weight loss and how commercialised the academic literature to a sustainable business, having raised more than $125m to date

She answers the question around do you need to be a healthcare professional to start and grow a health company, as Isabelle doesn’t come from that background herself

How she tested the idea and the considerations you need to take when testing and starting out that are unique to a health company, the different types of MVP you can have here

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April 2025 Energy Update