Moonshots with Peter Diamandis Claude Opus 4.5, White House "Genesis Mission" & Amazon's $50B AI Push w/ Emad Mostaque, Salim Ismail, Dave Blundin & Alexander Wissner-Gross | EP #211
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Nov 26, 2025 
Join Emad Mostaque, AI advocate and author, Salim Ismail, futurist and OpenExO founder, and Alexander Wissner-Gross, computer scientist, as they explore groundbreaking topics. They discuss the transformative White House Genesis mission aimed at uniting supercomputers for AI-driven science. The guests delve into Claude Opus 4.5’s innovative coding capabilities and its implications for automation. They also forecast AI's role in mitigating societal shifts and share thoughts on the future of land ownership and ethical implications of space mining.
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US Genesis Mission Treats Science As Compute
- The White House Genesis Mission treats science as a compute problem by linking supercomputers, federal datasets, and AI to speed discovery.
- If funded and open, it could double U.S. scientific productivity within a decade and accelerate breakthroughs in biotech, fusion, and quantum.
Genesis Compared To Manhattan Project
- Alex Wissner-Gross compares Genesis to the Manhattan Project because it unlocks scarce federal resources like datasets and compute at national scale.
- Positioning aims to accelerate innovation and compete geopolitically, especially versus China.
Opus 4.5 Signals Recursive Improvement
- Anthropic's Claude Opus 4.5 cuts token usage by 76% and outperforms incoming human hires on coding tests, signaling recursive self-improvement.
- This marks a shift where models can iterate on research and code, accelerating capability growth.
