Symptoms and Presentation of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

The podcast episode discusses the case of a 49-year-old female presenting with a rash, fever, ulcers, and red eyes. The most common initial symptom in this condition is fever. Stevens-Johnson syndrome and toxic epidermal necrolysis are severe mucocutaneous reactions triggered by medications. They are characterized by extensive necrosis and detachment of the epidermis and mucous membranes. The presentation includes flu-like prodrome, fever, skin lesions, and mucosal involvement such as oral ulcers and conjunctivitis. The cutaneous lesions are ill-defined, erythematous macules with purpura that can be very painful and tender to touch. The palms and soles are typically not involved. The patient may exhibit a positive Nikolski sign. It is important to recognize the clinical features and make a prompt clinical diagnosis to avoid missing this serious and potentially life-threatening condition.