The Incubator #386 - đ˘ HOT TOPICS 2025 COVERAGE - Thinking innovatively about nutrition research
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Dec 8, 2025 Dr. Ariel Salas challenges conventional feeding volume targets for preterm infants, proposing a trial that prioritizes fat-free mass over simple weight gain. He discusses the complexities of body composition changes, challenging standard practices in neonatal care. Salas emphasizes that understanding water shifts in the body can reveal more about growth quality than daily weights alone. He advocates for a fair testing approach to overcome clinical inertia and arbitrary standards, illuminating the need for innovation in nutrition research.
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Randomize To Challenge Feeding Dogma
- Do test entrenched feeding volume practices with randomized trials when equipoise exists.
- Use pragmatic, multicenter designs to challenge arbitrary standards like 140â160 vs 180â200 mL/kg/day.
Quality Over Quantity In Growth
- Body composition reveals growth quality beyond simple weight gain.
- Targeting fat-free mass is more likely to link to better long-term neurodevelopment.
Create Equipoise, Then Test Fairly
- Do acknowledge practice variation as an opportunity for equipoise and fair testing.
- Present alternative protocols and encourage randomized fair tests to avoid confounding.