Dr. Philip Mease, a renowned rheumatologist, presents compelling findings on the long-term safety of Bimekizumab for treating axial spondyloarthritis and psoriatic arthritis. Meanwhile, Dr. Eric Dein dives into the nuanced world of rheumatoid arthritis, discussing the critical distinctions between low disease activity and clinical remission. They also explore the implications of statin use alongside JAK inhibitors, shedding light on how these factors affect treatment strategies. Tune in for insights that could reshape RA management!
Effective management of rheumatoid arthritis is crucial to reduce the associated risk of osteoporosis and fractures linked to disease activity.
Sex-based differences in psoriatic arthritis highlight the need for tailored treatment strategies to improve outcomes for both genders.
Deep dives
Impact of Disease Activity on Osteoporotic Fractures in RA Patients
Patients with rheumatoid arthritis (RA) face an elevated risk of osteoporosis and subsequent fractures, particularly influenced by the level of disease activity. Research indicates that higher disease activity results in reduced bone density, leading to increased fracture rates, specifically hip fractures and major osteoporotic fractures. When patients experience high disease activity, they are more susceptible to these fractures compared to those in remission. Addressing this relationship emphasizes the need for effective management of RA to mitigate not only joint symptoms but also the associated risk of osteoporotic fractures.
Effect of COVID-19 Vaccination on RA Treatment
The administration of COVID-19 vaccines in patients with rheumatoid arthritis raises critical questions regarding the management of immunosuppressive therapies like JAK inhibitors and IL-17 agents. A study found that patients who held their medications during vaccination were more prone to flare-ups compared to those who continued therapy. Despite concerns, the results indicated that holding such treatments did not significantly enhance antibody responses against COVID-19. This insight reinforces the importance of continuity in RA treatment during vaccination periods to avoid exacerbations of the disease.
Sex Differences in Psoriatic Arthritis and Treatment Responses
Emerging research highlights significant sex-based differences in psoriatic arthritis, affecting pain levels, treatment responses, and disease progression. Females typically report greater pain and disability, while males demonstrate higher disease activity as measured by inflammatory markers. Moreover, treatment responses vary, with males often responding more favorably to biologic therapies, pointing to underlying gender-related biological mechanisms. Understanding these differences is vital for tailoring treatment strategies and improving outcomes for both genders in managing psoriatic arthritis.
Control RA, Build Stronger Bones:Dr. Jiha Lee talks with Dr. Rachel Elam
Hold or continue JAKi and IL-17 when receiving COVID boosters?:Dr. Bella Mehta
Long-term Safety Profile of Bimekizumab in axSpA and PsA:Dr. Philip Mease
Navigating Rheumatology Care in Humanitarian Crisis Settings:Dr. Antoni Chan talks with Dr. Martha Dhzhus
RA Roundup: Is LDA Inappropriate? What about Statins for JAKs?:Dr. Eric Dein
Sex Differences in Psoriatic Arthritis:Dr. Catherine Bakewell
Single v Double Lung Transplants for Disease-related ILD:Dr. Eric Dein talks with Dr. Harry Hurley
Sonelokimab in PsA: Phase 2 Data:Dr. Philip Mease
Treating SpA:Dr. Marina Magrey
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