Brock Purdy's return ignites Christian McCaffrey, George Kittle as 49ers thrash Cardinals
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Nov 17, 2025
Brock Purdy's triumphant return ignited the 49ers, leading to a significant victory over the Cardinals. He connected with George Kittle for two touchdowns and handed another to Christian McCaffrey, who dominates the league in scrimmage yards. The game saw San Francisco maintaining control despite Arizona's record penalties. However, the team might face challenges ahead with kicker Eddy Piñeiro's hamstring injury and linebacker Tatum Bethune's setback. The hosts also highlight the offense's newfound chemistry and Kittle's pivotal role in boosting team morale.
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insights INSIGHT
Purdy Restores Offensive Rhythm
Brock Purdy's return immediately restored timing and efficiency to the 49ers offense, making it feel like the group "never left."
That cohesion allowed George Kittle and Christian McCaffrey to dominate and opened up play-action and underneath work.
question_answer ANECDOTE
Injured Players Exiting In Pain
Jennifer Lee Chan describes Tatum Bethune leaving in a walking boot and being taken to the bus on a cart.
Eddy Piñeiro also showed hamstring issues, missing an extra point and walking postgame, raising concern.
volunteer_activism ADVICE
Proactively audition emergency kickers
The 49ers should bring in kickers early in the week for tryouts if Eddy Piñeiro is unavailable.
Scour free agents and prepare contingency plans rather than waiting until late in the week.
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Brock Purdy's return sparked the 49ers' offense, it also brought a much needed divisional win in a blowout against the Cardinals. Purdy threw for three touchdowns on Sunday, two of which went to a favorite target in tight end George Kittle and the other went to offensive fulcrum Christian McCaffrey, who leads the NFL in scrimmage yards this season through Week 11. Skyy Moore set the tone, returning the opening kickoff 98 yards to the 1-yard line, setting up a McCaffrey 1-yard touchdown run. San Francisco maintained control throughout the game, one in which Arizona did itself no favors accumulating a franchise-record 17 penalties. San Francisco did not escape Arizona unscathed though, as kicker Eddy Piñeiro suffered a hamstring injury in the third quarter that could force the team to bring in a new kicker. On this episode of '49ers Talk,' co-hosts Matt Maiocco and Jennifer Lee Chan break down San Francisco's outstanding performance against the Cardinals Sunday at State Farm Stadium. Matt and Jennifer discuss the impact of Purdy's return on the 49ers' offense during a crucial stretch, Kittle and CMC's dominance, and how injuries to both Piñeiro and linebacker Tatum Bethune might affect the team ahead of Monday's showdown with the Carolina Panthers.
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(0:00) 49ers did what they had to do to get win vs. Cardinals (3:00) Will the 49ers have to add a kicker because of Eddy Piñeiro's injury? (4:00) Brock Purdy's return dispels any QB controversy from media (12:00) Can CMC achieve 1,000-1,000 season? (14:00) This is the healthiest the 49ers have been on offense all season (17:30) The 49ers' defense forced three takeaways (25:00) What type of team are the 49ers? Can they bring this type of performance on MNF? (28:00) Robert Saleh will really have to earn his money down the stretch this season (30:00) Looking ahead, the 49ers need beat NFC playoff contenders Carolina, Chicago
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49ers Talk: A San Francisco 49ers Podcast