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The Curious Clinicians
33 - What's in a (drug's) name?
Sep 1, 2021
The podcast delves into the intriguing reasons behind drug names, focusing on Carbidopa-Levodopa's brand name Sinemet. It explores chiral molecules in drug effectiveness, the role of Carbidopa in managing nausea, and the fascinating origin stories of medication names like Montelucast and Warfarin.
13:42
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Quick takeaways
- Carbidopa inhibits peripheral conversion of levodopa, reducing gastrointestinal side effects in CineMet.
- Drug names like CineMet reflect therapeutic benefits and mechanisms of action, offering insights into development and effects.
Deep dives
Development and Mechanism of Action of Carbidopa Levodopa
Carbidopa Levodopa, known as CineMet, is a crucial medication for Parkinson's disease. The key pathology in Parkinson's involves a decrease in brain dopamine due to the loss of cells in the substantia nigra. Initially, directly giving dopamine to patients was ineffective since it does not cross the blood-brain barrier. However, researchers found that administering DOPA, a precursor to dopamine, allowed it to be converted to dopamine in the brain. Despite positive results, the initial formulation caused neutropenia issues, leading to further refinement.
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