ID:IOTS - Infectious Disease Insight Of Two Specialists 122. Moulds: Rare Invasive Moulds
Oct 20, 2025
Dr. Neil Stone, a consultant in infectious diseases at University College London Hospitals and a specialist in invasive fungal disease, joins the hosts for a deep dive into rare, invasive moulds. They explore the significance of Fusarium and Scedosporium species, discussing their clinical implications and high-risk patients. The conversation highlights the challenges of diagnosis and treatment, including susceptibility patterns and emerging antifungal options like olorofim. With intriguing cases and practical insights, this episode is a must-listen for medical professionals.
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Rare Moulds Target The Severely Immunosuppressed
- Fusarium, Scedosporium, and Lomentospora are ubiquitous environmental molds that cause severe disease mainly in highly immunosuppressed patients.
- These molds are often intrinsically drug-resistant, making early recognition and specialist input crucial.
Act Fast On Odd Blood Cultures And Skin Lesions
- If you see filamentous organisms in blood culture or febrile neutropenia with necrotic skin lesions, consider Fusarium urgently.
- Send cultures and biopsies promptly and involve reference labs for identification and susceptibility testing.
Skin Lesions Signal Dissemination
- Fusarium often causes disseminated infection with characteristic necrotic skin lesions due to hematogenous spread.
- Its ability to sporulate in vivo explains positive blood cultures and widespread skin deposits.