Better Brain Fitness (a Brainjo Production) Statins, Cholesterol, and Brain Health: Our Unfiltered Take
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Jul 31, 2025 Explore the intricate relationship between statins, LDL cholesterol, and brain health. The hosts delve into the link between midlife cholesterol levels and dementia risk, suggesting that better management could prevent many cases. They highlight the benefits of statins, including their anti-inflammatory properties, while addressing potential cognitive side effects. The discussion emphasizes the need for personalized healthcare approaches and the complexity of cholesterol’s role in both cardiovascular and cognitive health.
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LDL Cholesterol Links to Dementia
- Elevated LDL cholesterol in midlife is linked to increased dementia risk later.
- LDL cholesterol's dementia impact lessens after age 65, even showing longevity associations.
Vascular Disease in Dementia
- Most Alzheimer's cases have a vascular disease component affecting the brain's blood flow.
- LDL cholesterol contributes to atherosclerosis, impairing vascular function critical to brain health.
ApoB and LDL in Cardiovascular Risk
- Higher ApoB and LDL cholesterol strongly predict cardiovascular disease risk at population level.
- Most adults have metabolic dysfunction, making LDL's role in risk context-dependent.