Integrative GP Dr. Lily Thomas dives into the many complexities involved in fibromyalgia, a condition underpinned by chronic, systemic inflammation and neuroinflammation. Our Ambasssor Dr. Michelle Woolhouse opens the conversation discussing the many aetiologies of fibromyalgia which include oxidative stress, mitochondrial dysfunction, mast cell activation, microglia activation, peripheral and central sensitisation. They discuss common risk factors such as Vitamin D deficiency, gut health, and abnormal peripheral and central pain pathways, as well as others that can play a part in the development of fibromyalgia - which mainly impacts women aged 20 to 60 years of age. The gut is a major first focus for Dr. Thomas, who details connections between those with fibromyalgia and IBS, as well as how to investigate and treat through the gut. There’s also a deep discussion surrounding mitochondrial health and the development of fibromyalgia, due to the high concentration of mitochondria in skeletal muscle tissue as well as their impacts on damaging the nervous system and their ability to produce melatonin. Further to this, there is a fascinating technical discussion around gendered mast cells and microglia, and how they are shown to act differently depending on their sex, exposure to environmental toxins, dietary triggers, and sex hormones, all of which may be impacting patients with fibromyalgia. The brain and nervous system aspect can’t be forgotten as various areas of the brain known as the pain matrix contribute to both peripheral and central sensitisation with the focus on trigger points on reducing peripheral sensitisation having an upstream effect. This podcast is not to be missed for those who love technical details surrounding fibromyalgia and the multi-faceted aspects to treatment. Find today's transcript and show notes here: https://www.fxmedicine.com.au/podcast/fibromyalgia-central-sensitisation-brain-architecture-and-pain-matrix-dr-michelle-woolhouse Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics https://pages.blackmores.com.au/FXM-signup.html ***DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***