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JAMA Author Interviews

Does Treating Attention-Deficit/Hyperactivity Disorder Reduce Mortality?

Mar 12, 2024
Frances R. Levin is a leading expert in ADHD treatment and serves as the Kennedy Levy Professor of Psychiatry at Columbia University. In this discussion, she delves into a groundbreaking study showing that ADHD medications can significantly reduce mortality rates, including accidental poisonings. Frances highlights the importance of personalized treatment, addressing concerns around stimulant misuse and cardiovascular risks. The conversation also explores innovative research methods that enhance the understanding of ADHD's impact on behaviors and health outcomes.
13:35

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Quick takeaways

  • Pharmacotherapy for ADHD significantly reduces all-cause and unnatural-cause mortality, emphasizing the critical importance of effective treatment strategies.
  • The study employed target trial emulation to enhance validity while observing ADHD medication's effects, though it cannot establish definitive causation.

Deep dives

Importance of Treating ADHD

Addressing the treatment of Attention Deficit Hyperactivity Disorder (ADHD) is crucial due to its links to serious health risks. Individuals with ADHD have been identified as being at a higher risk for both morbidity and mortality, which challenges the notion in some circles that ADHD is not a significant concern. The recent study examined a substantial cohort of nearly 150,000 individuals diagnosed with ADHD, revealing a notable decrease in all-cause and unnatural-cause mortality rates among those receiving pharmacotherapy, primarily stimulants. This highlights the potential life-saving benefits of effective treatment strategies for this population.

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