Becker’s Healthcare Podcast Simon Nazarian, Executive Vice President and Chief Digital and Technology Officer at City of Hope
Dec 24, 2025
Simon Nazarian, Executive Vice President and Chief Digital and Technology Officer at City of Hope, explores the transformative power of technology in healthcare. He argues that AI is essential for improving patient outcomes and driving operational efficiency, urging health systems not to stand still. Nazarian discusses the importance of thoughtful tech investments focused on impact, security concerns, and the need for careful evaluation of new technologies. Highlighting opportunities in data, precision medicine, and virtual care, he emphasizes the role of leadership in fostering innovation.
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Episode notes
Career Path Shapes Perspective
- Simon described his career arc from Kaiser to McKinsey to Optum and now City of Hope.
- He emphasized cross-industry experience as valuable for healthcare transformation.
Healthcare At An Inflection Point
- Healthcare sits at an inflection point with data, compute power, and AI converging to accelerate discovery and care.
- Simultaneously, systems face financial pressure, workforce shortages, and rising cyber risk that complicate adoption.
Make Security Foundational
- Treat security as a foundational requirement and embed it into every build and deployment.
- Protect PHI and PII by keeping security top-of-mind across the organization.