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Dr. Nir Barzilai is a geroscientist, Chaired Professor of Medicine and Genetics, and the founder and principal investigator of the Einstein Nathan Shock Center and the Glenn Center for Excellence in Biology of Aging. He also studies families of centenarians that have provided genetic and biological insights on the protection against aging—with several drugs developed based, in part, on these paradigm-changing studies. He is also leading the TAME (Targeting/Taming Aging with Metformin) trial to prove to the FDA that aging can be delayed and to allow for next-generation interventions.

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In this episode we discuss (audio version / Apple Subscriber version):

The hallmarks of aging (9:01 / 7:10)
What causes the hallmarks of aging? (15:40 / 13:49)
Dr. Barzilai’s research on centenarians (23:16 / 21:25)
Why living to 100+ years is good for the economy (24:54 / 23:03)
What enables someone to live to 100 years old? (29:30 / 25:20)
Taking growth hormone and Metformin have different effects based on your age (36:58 / 32:48)
The connection between HDL cholesterol and longevity (43:36 / 39:26)
Dr. Barzilai’s research on Metformin (56:23 / 52:13)
How Metformin works in the body and on muscle growth (1:04:51 / 1:00:41)
Dr. Barzilai’s personal longevity (1:42:05 / 1:37:55)

Learn more about the Longevity Genes Project and the TAME Trial.

Get a copy of Age Later: Health Span, Life Span, and the New Science of Longevity

Byzantium and Italy, with Robin Pierson (History of Byzantium), (ep. 2, ENGLISH)