The Stem Cell Podcast

Ep. 70: “New MS Therapy” Featuring Dr. Mark Freedman

Jul 19, 2016
Dr. Mark Freedman, a neurologist and MS researcher from the University of Ottawa, discusses groundbreaking stem cell therapies for multiple sclerosis. He explains the immune reboot hypothesis, which resets the immune system to examine triggers of MS. Freedman shares surprising durable remission cases where patients did not experience relapse post-treatment. He also highlights the ideal candidates for this therapy and the complexities of integrating stem cell approaches with existing treatments. His insights into MS and the evolving landscape of treatment are both enlightening and hopeful.
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INSIGHT

Genome Editing Enables Primate Disease Models

  • New genome editing allows efficient creation of disease models in non-human primates.
  • Marmoset IL2RG mutants were made to model X‑SCID and permit human cell transplantation studies.
INSIGHT

Immune Reboot Can Stop Aggressive MS

  • Rebooting the immune system by wiping and regenerating it can eliminate MS activity long-term in aggressive cases.
  • Mark Freedman discovered many treated patients did not redevelop disease after immune-system reset.
INSIGHT

Genetics Plus Environment Shape MS Risk

  • MS likely arises from interactions between genetic susceptibility and environmental triggers shaping the immune repertoire.
  • Identical genetics do not guarantee identical immune outcomes due to random immune gene assembly.
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