

003: Septic Reactions with Anne Eder
Apr 11, 2016
Dr. Anne Eder, Chief of Blood Services at the NIH, shares her expertise on septic transfusion reactions. She highlights the critical risks of bacterial contamination in platelets and discusses advancements in detection methods. The conversation covers the complexities of recognizing symptoms and diagnosing these potentially fatal reactions. Dr. Eder emphasizes the importance of collaboration between transfusion services and clinicians. Additionally, she explores the implications of hemovigilance programs and groundbreaking technologies to enhance blood transfusion safety.
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Early Career Case That Shaped Her Focus
- Dr. Anne Eder witnessed a platelet transfusion cause rapid deterioration and ICU admission early in her training.
- That case motivated her lifelong focus on transfusion safety.
Platelets Pose Higher Bacterial Risk
- Septic transfusion reactions from platelets are a far larger present threat than HIV/HBV/HCV transmission.
- Platelets cause higher sepsis risk because they are stored at room temperature with agitation.
Prevent Entry With Donor Screening And Diversion
- Limit bacterial entry by screening donors, checking temperatures, and deferring those on antibiotics.
- Use sterile single-use equipment, skin antisepsis, and divert the initial blood volume after venipuncture.