

Gluten, MTHFR, Mast Cells, and More | Office Hours (Ep 155)
In this solo episode of the Bendy Bodies Podcast, Dr. Linda Bluestein tackles a series of complex listener questions originally submitted by clinicians after her guest appearance on The Curbsiders internal medicine podcast. From the flaws in the EDS diagnostic criteria to the misunderstood role of MTHFR gene (methylenetetrahydrofolate reductase), SVT (supraventricular tachycardia), celiac disease, and mast cell medications, she offers guidance, clarity, and practical advice. She also digs into how to find a provider who actually understands dysautonomia and shares personal hacks that empower patients to ask smarter questions during appointments. This episode is a toolkit for patients and providers alike, packed with real-world insights you won’t want to miss.
Takeaways:
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Why Beighton scoring alone doesn’t cut it for diagnosing EDS
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The truth about MTHFR variants and their link to EDS
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The overlap between SVT, POTS, and when to worry
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What to ask your doctor if you’re not sure they "get" dysautonomia
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A breakdown of meds like LDN, ketotifen, and cromolyn—and who they help most
References:
The Curbsiders Podcast EP 480 - Hypermobility with Dr. Linda Bluestein: https://thecurbsiders.com/curbsiders-podcast/480-hypermobility-with-dr-linda-bluestein
https://pubmed.ncbi.nlm.nih.gov/38523329/?utm_source=chatgpt.com
hEDS Diagnostic Criteria Checklist
Red Flags Guide (credit: Clair A. Francomano, MD): https://www.bendybodiespodcast.com/p/redflags/
Hope for Hypermobility
Find the episode transcript here
Bendy Bodies EP 133: How Internists Think About Complex Illness with Dr. Matthew Watto: https://www.bendybodiespodcast.com/how-internists-think-about-complex-illness-with-dr-matthew-watto-ben-133/
Bendy Bodies EP 139: Hidden Histamine Threats with Dr. Theoharis Theoharides: https://www.bendybodiespodcast.com/hidden-histamine-threats-with-dr-theoharis-theoharides-ep-139/
Cromolyn Douche Article: https://pubmed.ncbi.nlm.nih.gov/30964355/
LDN episode: https://www.bendybodiespodcast.com/lower-your-eds-pain-office-hours-ep-138/
LDN resource: https://www.bendybodiespodcast.com/p/low-dose-naltrexone-ldn-for-chronic-pain-eds/
Want more Dr. Linda Bluestein, MD?
Website: https://www.hypermobilitymd.com/.
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X: https://twitter.com/BluesteinLinda
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