VJHemOnc Podcast cover image

VJHemOnc Podcast

Latest AML therapies: novel preparations and first in class agents

Sep 14, 2020
Guests Thomas Cluzeau, Naval Daver, and Andrew Wei discuss the latest AML therapies, including the use of CPX351 as a potential cure for certain patients, the safety and efficacy of Magrola MAB in combination with azacitidine, the high response rates and safety profile of treatment for TP53 AML patients, and updates on Venetoclax plus low dose Cytarabine study in previously untreated older AML patients.
16:07

Podcast summary created with Snipd AI

Quick takeaways

  • CPX351, a dual drug liposomal encapsulation of Cytarrabine and Darna Ruberson, has shown benefits in remission rates and overall survival for poor risk acute myeloid leukemia patients.
  • The Phase 1B study of Magrola MAB, an anti-CD47 antibody, in combination with azocytidine, shows promise in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) by allowing macrophages to phagocytize tumor cells, leading to high response rates and manageable side effects.

Deep dives

Therapies for Poor Risk Acute Myeloid Leukemia

One therapy discussed for poor risk acute myeloid leukemia is CPX351, a dual drug liposomal encapsulation of Cytarrabine and Darna Ruberson. This therapy has shown benefits in remission rates as well as an increase in overall survival. The analysis of CPX351 treated patients in France confirms the data published by Geoffrey Ransette, and the long-term follow-up of the phase-two study shows continued improvement in overall survival after five years.

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.
App store bannerPlay store banner

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode