The SimKit Podcast
The Beans or Brain?- The ACORN trial and effects of cefepime and pip-tazo on neuro and renal outcomes
Feb 20, 2024
Dive into the critical examination of cefepime and piperacillin-tazobactam in treating sick patients. Unpack the ACORN Trial's findings on acute kidney injury and neurologic dysfunction. Discover how these antibiotics impact patient outcomes in the Emergency Department. A fabricated patient case sheds light on the trial's implications for clinical practice. It's a fascinating discussion that weighs the risks and benefits of these common antibiotic choices.
21:25
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Quick takeaways
- The ACORN trial reveals no significant difference in acute kidney injury rates between piperacillin-tazobactam and cefepime in hospitalized adults.
- Cefepime is linked to a higher incidence of neurologic dysfunction compared to piperacillin-tazobactam, highlighting the importance of antibiotic selection.
Deep dives
Overview of the ACORN Trial
The ACORN trial investigates the safety profile of two commonly used antibiotics, piperacillin-tazobactam (PipTazo) and cefepime, in hospitalized adults with suspected infections. This trial addresses a critical concern regarding potential acute kidney injury (AKI) and neurologic dysfunction associated with these medications. The study involves a pragmatic, open-label, randomized design, enrolling over 2,500 patients across emergency and intensive care settings, which helps ensure robust and clinically relevant results. The primary aim is to determine if one antibiotic leads to better renal outcomes or reduced rates of neurologic complications in this patient population.
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