Post–Cardiac Arrest Syndrome with Dr. Alexis Topjian-Part 2

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Jan 8, 2024

Dr. Alexis Topjian discusses post-cardiac arrest care, including therapeutic hypothermia trials in pediatric patients and the impact of temperature management on outcomes. The podcast also highlights the importance of clinical pathways, neuro-prognostication, and building systems to improve patient care.

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Introduction

00:00 • 2min

Therapeutic Hypothermia Trials in Pediatric Cardiac Arrest

02:10 • 11min

Discussion on Cooling Duration and Use of Clinical Pathways

13:36 • 2min

Importance of Neuro-Prognostication in Post-Cardiac Arrest Children

15:28 • 8min

Building Systems to Improve Patient Care

23:17 • 3min

Alexis Topjian, MD, MSCE is a Professor of Anesthesiology and Critical Care at the University of Pennsylvania. She is an intensivist at the Children’s Hospital of Philadelphia where she also serves as the Fellowship Director of Neurocritical Care, Director of the Pediatric Neurocritical Care Program, and the Director of Faculty Development. She also was the first author on the 2019 Pediatric Post–Cardiac Arrest Care Scientific Statement from the American Heart Association.

Learning Objectives:

By the end of this podcast, listeners should be able to describe:

The clinical characteristics of post-cardiac arrest syndrome.
The general goals and guiding principles of high quality post-cardiac arrest care.
An evidence-based approach to diagnostic testing and monitoring of the post-cardiac arrest patient.
An evidence-based approach to supportive treatment of the post-cardiac arrest patient with an emphasis on targeted temperature management.
Relevant prognostic factors and best practices communicating prognosis to families of children who have suffered a cardiac arrest.

References:

Topjian AA, de Caen A, Wainwright MS, Abella BS, Abend NS, Atkins DL, Bembea MM, Fink EL, Guerguerian AM, Haskell SE, Kilgannon JH, Lasa JJ, Hazinski MF. Pediatric Post-Cardiac Arrest Care: A Scientific Statement From the American Heart Association. Circulation. 2019 Aug 6;140(6):e194-e233. doi: 10.1161/CIR.0000000000000697. Epub 2019 Jun 27. PMID: 31242751.

Moler et al. Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med. 2015 May 14;372(20):1898-908. doi: 10.1056/NEJMoa1411480. Epub 2015 Apr 25. PMID: 25913022; PMCID: PMC4470472.

Moler et al; THAPCA Trial Investigators. Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med. 2017 Jan 26;376(4):318-329. doi: 10.1056/NEJMoa1610493. Epub 2017 Jan 24. PMID: 28118559; PMCID: PMC5310766.

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