Psoriasis Uncovered Ep. 180 "Breaking Down the Immune Pathway Driving Psoriatic Disease"
Nov 15, 2022
Join Dr. Jason Hawkes, an Associate Professor of Dermatology at UC Davis, as he dissects the immune pathways at play in psoriasis and psoriatic arthritis. He highlights the crucial IL-17 and IL-23 pathways and their roles in developing targeted treatments. Discover the significance of innate immune cells and how they differ from traditional T cells. With advancements in biologic therapies and promising new treatments like bimikizumab and ducravacitinib, there's hope on the horizon for personalized care in managing this chronic condition.
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Chronic Immune Feed-Forward Loop
- Psoriasis is driven by a chronic feed-forward inflammatory mechanism involving IL-17 and IL-23.
- Resident memory T cells in skin and joints perpetuate this sustained inflammation.
Immune System Drives Psoriasis
- Early observations linked psoriasis improvement to immune suppression from chemotherapy and transplant medications.
- Discovery of T cells' key role led to targeted therapies blocking immune signals like TNF, IL-23, and IL-17.
TNF's Role in Psoriasis Pathway
- TNF indirectly promotes the IL-23/IL-17 pathway and synergizes with IL-17 to drive psoriasis.
- Blocking TNF reduces this feed-forward inflammation but is less direct than IL-17 or IL-23 inhibitors.