Adverse Events from Nitrate Administration during Right Ventricular Myocardial Infarction: A Systematic Review and Meta-Analysis

The current guidelines recommend against administering nitrates to patients with right ventricular myocardial infarction due to concerns about decreasing preload and reducing cardiac output. However, a systematic review and meta-analysis challenge this recommendation based on evidence from a cohort study of 40 patients. The meta-analysis included over 1,100 patients and found no statistically significant difference in adverse events between patients receiving nitrate administration and those with inferior myocardial infarction. The authors concluded that nitrate administration in right ventricular myocardial infarction may not have a significant negative effect and further studies are needed for clearer guidelines.