Dr. Chapa’s Clinical Pearls. Continue LDA PP For PreE Prevention? New Data
Jul 15, 2025
Is it beneficial to continue low-dose aspirin postpartum for preeclampsia prevention? New research sheds light on this clinical question. The podcast delves into a randomized clinical trial linking postpartum aspirin use to maternal cardiac health, specifically NT-proBNP levels. While findings suggest that continuing aspirin may not show immediate benefits, it raises important discussions about its effects during pregnancy. Listeners will gain insights into recent publications enhancing their understanding of aspiring treatment strategies.
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Postpartum Aspirin Not Yet Proven
- Continuing low-dose aspirin postpartum does not reduce hospital readmission or cardiac stress in preeclampsia patients.
- Despite a lower diagnosis rate of postpartum preeclampsia, the difference was not statistically significant.
NT-proBNP Limits in Preeclampsia
- NT-proBNP levels are used as a biomarker for cardiac strain but have sensitivity and specificity limitations in preeclampsia.
- The study found no difference in NT-proBNP levels between aspirin and placebo groups postpartum, indicating no cardiac benefit.
C-Section Raises Cardiovascular Risk
- Cesarean delivery is associated with a higher risk of postpartum preeclampsia and cardiovascular events.
- Higher rates of cesarean in aspirin group complicate interpretation of aspirin's effect on postpartum preeclampsia.